焦平

作者: 时间:2021-07-02 点击数:

姓名

焦平

职称

教授

办公地点

再生医学科学研究所302

办公电话

0431-85619289

邮箱

jiao_ping@jlu.edu.cn

教育背景

1997-2002 william威廉官网医学院临床医学系 学士

2002-2005 william威廉官网生物化学与分子生物学 硕士2005-2009 william威廉官网医员工物工程学 博士

2007-2009 美国布朗大学医学院内分泌系 联合培养博士

工作经历

2009-2012 美国布朗大学医学院 Research Associate

2012-2022 william威廉官网 副教授

2022- william威廉官网 教授/博士生导师

主讲课程

分子细胞生物学;干细胞生物学实验

分子生物学实验技术;生物医学工程学

研究领域

1、代谢性疾病机制及药物开发

2、干细胞与代谢性疾病

科研成果

代表性文章:

1. Lu Y, Zhao J, Tian Y, Shao D, Zhang Z, Li S, Li J, Zhang H, Wang W, Jiao P*, Ma J*. Dichotomous Roles of Men1 in Macrophages and Fibroblasts in Bleomycin-Induced Pulmonary Fibrosis. Int J Mol Sci. 2022; 23(10):5385.

2. Zhao T, Zhao C, Lu Y, Lin J, Tian Y, Ma Y, Li J, Zhang H, Yan W, Jiao P*, Ma J*. Noxa and Puma genes regulated by hTERT promoter can mitigate growth and induce apoptosis in hepatocellular carcinoma mouse model. J Cancer. 2022;13(6):2001-2013.

3. Lu Y, Ma J, Lin J, Tian Y, Ma Y, Wang W, Li J, Zhang H, Jiao P*. Cell Membrane Breakage and Triggering T Cell Infiltration are Involved in Human Telomerase Reverse Transcriptase (hTERT) Promoter-driven Novel Peptide KK-64 for Liver Cancer Gene Therapy. Bioengineered. 2021;12(2):12708-12721.

4. Lin J, Lu Y, Wang B, Jiao P*, Ma J*. Analysis of immune cell components and immune-related gene expression profiles in peripheral blood of patients with type 1 diabetes mellitus. J Transl Med, 2021;19(1): 319.

5. Zhou C, Ma J*, Lu Y, Zhao W, Xu B, Lin J, Ma Y, Tian Y, Zhang Q, Wang W, Yan W, Jiao P*. TERT promoter regulating melittin expression induces apoptosis and G0/G1 cell cycle arrest in esophageal carcinoma cells. Oncol Lett. 2021;21(1):16.

6. Zhao T, Ma J, Li L, Teng W, Tian Y, Ma Y, Wang W, Yan W*, Jiao P*. MKP-5 relieves lipotoxicity-induced islet β-cell dysfunction and apoptosis via regulation of autophagy. Int J Mol Sci. 2020;21(19):7161.

7. Lu Y, Ma J*, Zhao J, Song Z, Zhou C, Liu X, Teng W, Wang W, Zhang Q, Yan W, Jiao P*. The Role of MKP-5 in Adipocyte-Macrophage Interactions during Obesity. Obes Facts. 2020;13(1):86-101.

8. Song Z, Ma J, Lu Y, Zhou C, Zhao T, Ai X, Wei X, Lin J, Wang W, Yan W, Jiao P*. The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis. Exp Cell Res, 2019;382(1):111467.

9. Zhou C, Ma J, Su M, Shao D, Zhao J, Zhao T, Song Z, Meng Y, Jiao P*. Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells. Cancer Cell Int. 2018;18:53.

10. Jiao P, Feng B, Li Y, He Q, Xu H*. Hepatic ERK activity plays a role in energy metabolism. Mol Cell Endocrinol. 2013;375(1-2):157-166.

11. Jiao P, Feng B, Ma J, Nie Y, Paul E, Li Y, Xu H*. Constitutive activation of IKKβ in adipose tissue prevents diet-induced obesity in mice. Endocrinology. 2012;153(1):154-165.

12. Jiao P, Feng B, Xu H. Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis. PLoS One. 2012;7(7):e41168.

13. Feng B#, Jiao P#, Yang Z, Xu H*, MEK/ERK pathway mediates insulin-promote degradation of MKP-3 protein in liver cells. Mol Cell Endocrinol. 2012;361(1-2):116-123.

14. Jiao P, Ma J, Feng B, Zhang H, Diehl JA, Chin YE, Yan W, Xu H*. FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. Obesity (Silver Spring). 2011;19(3):483-491.

15. Jiao P, Chen Q, Shah S, Du J, Tao B, Tzameli I, Yan W, Xu H*. Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes. 2009 Jan;58(1):104-115.

16. Jiao P, Xu H*. Adipose inflammation: cause or consequence of obesity-related insulin resistance. Diabetes Metab Syndr Obes. 2008; 1:25-31.

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