科研成果 |
吉林省省域拔尖人才(吉林省人才政策3.0版-D类人才);吉林省药理学会理事;吉林省药学会药理专业委员会委员;中国药理学会神经精神药理学专业委员会第二届青年委员会委员。 主持(含共同)科研项目: (1)国家自然科学基金青年科学基金项目,Aβ-tau对压后皮层神经编码的影响与AD小鼠认知障碍间的关系及多聚唾液酸的干预作用,2024-01 至 2026-12 (2)吉林省科技发展计划国际合作项目,基于cGAS/STING/NLRP3炎性小体信号通路研究人参皂苷Rd改善衰老相关认知功能减退的作用及机制,2024-01 至 2026-12 (3)中国博士后科学基金面上项目(74批),基于压后皮层内锥体神经元-中间神经元微环路研究PSA对AD小鼠学习记忆障碍的改善作用及其神经编码机制,2024-01 至 2025-12 (4)william威廉官网学科交叉青年创新团队项目,阿尔兹海默症AI大模型,2024-01 至 2026-12 (5)william威廉官网有组织科研专项,用于生物医学领域的近红外量子点光源,2024-01 至 2026-12 (6)william威廉官网白求恩计划项目,基于RSC微环路研究PSA改善AD小鼠认知障碍的神经编码机制,2023-05 至 2025-04 (7)william威廉官网“唐敖庆学者”青年学者校外引进科研支持专项,2023-01 至 2027-12 (8)Young Glia日本-德国国际合作研究项目铂金奖,Studying microglia interaction in the process of synapse pruning in health and disease,已结项。 代表性学术论文: [1] Sun, W.#, Choi, I.#, Stoyanov, S., Senkov, O., Ponimaskin, E., Winter, Y., Pakan, J. M.* & Dityatev, A.* (2021). Context value updating and multidimensional neuronal encoding in the retrosplenial cortex. Nature Communications, 12(1), 6045. [2] Stoyanov, S.#, Sun, W.#, Düsedau, H. P., Cangalaya, C., Choi, I., Mirzapourdelavar, H., Baidoe-Ansah, D., Kaushik, R., Neumann, J., Dunay, I. R.* & Dityatev, A.* (2021). Attenuation of the extracellular matrix restores microglial activity during the early stage of amyloidosis. Glia, 69(1), 182-200. [3] Sun, W.#, Suzuki, K#., Toptunov, D., Stoyanov, S.*, Yuzaki, M., Khiroug, L., & Dityatev, A.* (2019). In vivo two-photon imaging of anesthesia-specific alterations in microglial surveillance and photodamage-directed motility in mouse cortex. Frontiers in Neuroscience, 13, 421. (该文章入选Neural Technology Editor’s Pick 2021) [4] Cangalaya, C., Wegmann, S., Sun, W., Diez, L., Gottfried, A., Richter, K., Stoyanov, J., Pakan, J., Fischer, K. & Dityatev, A.* (2023). Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy. Brain, Behavior, and Immunity 110, 245-259. [5] Jahreis, K., Brüge,A., Borsdorf, S., Müller, F. E., Sun, W., Jia, S., Kang,D., Boesen, N., Shin, S., Lim, S., Koroleva, A., Satała, G., Bojarski, A., Rakuša, E., Fink, A., Doblhammer-Reiter,G., Kim, Y., Dityatev, A.,* Ponimaskin, E.,* & Labus, J.,*(2023). Amisulpride as a potential disease-modifying drug in the treatment of tauopathies. Alzheimer's & Dementia, 1-16. 发明专利: [1] 5-HT7 antagonist for the treatment of dementia-associated tauopathies, EP3856156, 2021.08.04. [2] Treatment of dementia-associated tauopathies, US 2022/0023257 A1, 2022.01.27. |